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I David Goldman Selected Research

Reduced Folate Carrier Protein

3/2007The molecular identity and characterization of a Proton-coupled Folate Transporter--PCFT; biological ramifications and impact on the activity of pemetrexed.
2/2006The inverse relationship between reduced folate carrier function and pemetrexed activity in a human colon cancer cell line.
8/2005The relationship between folate transport activity at low pH and reduced folate carrier function in human Huh7 hepatoma cells.
1/2005Preservation of folate transport activity with a low-pH optimum in rat IEC-6 intestinal epithelial cell lines that lack reduced folate carrier function.
1/2004A prominent low-pH methotrexate transport activity in human solid tumors: contribution to the preservation of methotrexate pharmacologic activity in HeLa cells lacking the reduced folate carrier.
4/2003Decreased expression of the reduced folate carrier and folypolyglutamate synthetase is the basis for acquired resistance to the pemetrexed antifolate (LY231514) in an L1210 murine leukemia cell line.
11/2002A novel folate transport activity in human mesothelioma cell lines with high affinity and specificity for the new-generation antifolate, pemetrexed.

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I David Goldman Research Topics

Disease

21Hereditary Folate Malabsorption
11/2020 - 12/2006
19Neoplasms (Cancer)
01/2021 - 11/2002
6Mesothelioma
04/2008 - 11/2002
5Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
04/2008 - 02/2006
3Leukemia
01/2005 - 06/2002
2Megaloblastic Anemia
04/2013 - 06/2002
2Breast Neoplasms (Breast Cancer)
02/2005 - 08/2003
1Neurodegenerative Diseases (Neurodegenerative Disease)
01/2019
1Peripheral T-Cell Lymphoma (Lymphoma, T Cell, Peripheral)
09/2013
1biotin-responsive Basal ganglia disease
04/2013
1Ataxia Telangiectasia (Louis Bar Syndrome)
04/2008
1Colonic Neoplasms (Colon Cancer)
02/2006
1Hepatocellular Carcinoma (Hepatoma)
08/2005

Drug/Important Bio-Agent (IBA)

24Folic Acid (Vitamin M)FDA LinkGeneric
01/2021 - 11/2002
19Proton-Coupled Folate TransporterIBA
01/2021 - 09/2008
16Folic Acid AntagonistsIBA
01/2021 - 11/2002
14Pemetrexed (MTA)FDA Link
01/2018 - 11/2002
7Reduced Folate Carrier ProteinIBA
03/2007 - 11/2002
4Leucovorin (Folinic Acid)FDA Link
05/2014 - 04/2003
3Proteins (Proteins, Gene)FDA Link
11/2020 - 08/2003
3Methotrexate (Mexate)FDA LinkGeneric
05/2014 - 01/2004
310-propargyl-10-deazaaminopterinFDA Link
05/2014 - 09/2013
2Folic Acid TransportersIBA
04/2013 - 12/2010
2Thiamine (Aneurin)FDA Link
04/2013 - 06/2002
2Pharmaceutical PreparationsIBA
02/2005 - 01/2004
1Aspartic Acid (Aspartate)FDA Link
12/2010
1Glutamine (L-Glutamine)FDA Link
11/2010
1Caffeine (No Doz)FDA LinkGeneric
04/2008
1Trimetrexate (JB11)FDA Link
07/2007
1Erlotinib Hydrochloride (CP 358,774)FDA Link
06/2007
1Protons (Proton)IBA
12/2006
1PurinesIBA
10/2006
11- (9- deazaadenin- 9- yl)methyl- 3- hydroxy- 4- methylthiomethylpyrrolidineIBA
10/2006
1AdenineFDA LinkGeneric
10/2006
15'-methylthioadenosine phosphorylase (methylthioadenosine nucleosidase)IBA
10/2006
1ThymidineIBA
02/2005
1Ligases (Synthetase)IBA
04/2003
1GTP-Binding Proteins (G-Protein)IBA
11/2002
1Thymidine Monophosphate (TMP)IBA
06/2002
1Thiamine MonophosphateIBA
06/2002

Therapy/Procedure

1Therapeutics
01/2015
1Drug Therapy (Chemotherapy)
06/2012